سامانه همایش های دانشگاه جیرفت

صفحه اصلی / سومین همایش بین المللی و چهارمین همایش ملی کشاورزی، محیط زیست و امنیت غذایی

Medicinal Plants in Alzheimer's Disease Prevention and Treatment: Recent Advances in Biotechnology Approaches and Molecular Insights

نویسندگان :

Hosein Yousefi¹

1- دانشگاه تهران مرکزی

کلمات کلیدی :

Alzheimer's disease،medicinal plants،biotechnological innovations،bioactive compounds،neuroprotective therapies

چکیده :

Alzheimer's disease (AD), a major cause of dementia, is increasing in prevalence and currently lacks effective disease-modifying treatments. Traditional therapies offer limited symptomatic relief, fueling interest in alternative approaches like medicinal plants. Numerous plant-derived compounds, such as curcumin from Curcuma longa, ginkgolides from Ginkgo biloba, and bacosides from Bacopa monnieri, have shown neuroprotective potential by targeting key pathological features of AD, including amyloid-beta aggregation, oxidative stress, and neuroinflammation. Biotechnological advancements, including nanotechnology, plant cell cultures, and genetic engineering, have improved the bioavailability and therapeutic efficacy of these compounds, addressing challenges in traditional plant extraction and delivery methods. In particular, nanoparticle delivery systems have enhanced curcumin’s solubility and stability, leading to improved cognitive function in AD models, while plant cell cultures have enabled the production of high concentrations of bioactive compounds. Molecular mechanisms revealed through recent studies indicate that these compounds modulate critical AD pathways, such as amyloid-beta aggregation and tau phosphorylation, as well as enhance synaptic plasticity and mitochondrial function. The findings suggest a promising future for integrating plant-based therapies into AD treatment strategies, with the potential to slow disease progression and complement existing treatments. Further research, combined with biotechnological innovations, will be crucial for maximizing the therapeutic potential of medicinal plants in AD care. This review systematically evaluated studies from 2020 to 2024, focusing on the application of biotechnological methods to enhance plant-based therapies for AD.