سامانه همایش های دانشگاه جیرفت

صفحه اصلی / سومین همایش بین المللی و چهارمین همایش ملی کشاورزی، محیط زیست و امنیت غذایی

Protective Role of Tigernut (Cyperus esculentus) Against Fluoxetine-Induced Reproductive Dysfunction in Male Wistar Rats

نویسندگان :

Samuel Olumide Ajani¹ Kudus Oyeyebi Dolapo² Olumide Odunayo Akinniy³

1- University of Ibadan, Nigeria 2- University of Ibadan, Nigeria 3- University of Ibadan, Nigeria

کلمات کلیدی :

Tigernut،Fluoxetine،Histopathology،Rat،Testes،Semen

چکیده :

Purpose: Fluoxetine (FLX), a commonly prescribed selective serotonin reuptake inhibitor (SSRI) for treating psychiatric disorders, has been linked to male reproductive toxicity, necessitating the search for protective agents. This study investigates the protective role of tiger nut (Cyperus esculentus) in mitigating FLX-induced reproductive dysfunction in male Wistar rats. Research Methods: A total of 30 male Wistar rats were randomly assigned into five groups. Group I served as the control and received distilled water, Group II received FLX (20 mg/kg), while Groups III, IV, and V received FLX alongside low (200 mg/kg), medium (400 mg/kg), and high (800 mg/kg) doses of Cyperus esculentus extract, respectively, for 21 days. At the end of the experiment, haematological parameters, semen quality, sperm motility, and gonadometric indices were assessed. Results: FLX administration significantly altered haematological parameters, including packed cell volume (PCV), white blood cell (WBC) count, platelet count, and eosinophil percentages. Co-administration with Cyperus esculentus mitigated these alterations, with the highest dose exhibiting the most pronounced effect. While FLX did not significantly impact overall semen quality, it caused a mild reduction in sperm motility, which was restored in a dose-dependent manner with Cyperus esculentus supplementation. Gonadometric indices were also negatively affected by FLX but were partially normalized with Cyperus esculentus co-administration. Conclusion: This study suggests that Cyperus esculentus supplementation may offer protective effects against FLX-induced reproductive and haematological alterations. Patients undergoing antidepressant therapy could potentially benefit from tiger nut co-administration to preserve reproductive health.